The Research Behind Oligenics and Its Components
Oligenics is informed by more than two decades of published research. That includes studies on the ingredient it's made from, and independent peer-reviewed work on the biological compounds that ingredient contains. This page brings that research together in one place.
This page has two sections. The first covers published studies on the ingredient used in Oligenics, a standardised extract of fertilised and incubated chicken eggs. The second is a library of independent research on the individual compounds and signalling pathways found in that extract. The Section Two studies were not conducted on Oligenics and should not be read as direct evidence of what the product does.
Section One: Research on the ingredient in Oligenics
These studies were conducted on the same standardised chicken embryo extract used in Oligenics, before it was offered under the Oligenics name. They were carried out by researchers affiliated with the ingredient's manufacturer. The human studies used the original preparation at different numbers of capsules a day from the standard Oligenics serving of 2 capsules a day, for set study periods. For example, the lipid study used 4 capsules a day for 60 days, and the oxidative-stress study used 2 capsules a day for 3 weeks. Their results should not be read as applying to Oligenics at any dose.
1. Mihaescu G, Olinescu R, Oancea F (2005). Romanian Journal of Internal Medicine, 43(1-2), 133-139. View study →
A 60-day study in 40 adults aged 50 to 75. Each participant served as their own control. It examined changes in blood lipid markers following daily intake of the embryonary peptide preparation.
Human study · Lipid markers · PubMed 16739873
2. Mihăescu GF, Olinescu RM, Grigorescu A (2006). Romanian Journal of Internal Medicine, 44, 443-453. View study →
A follow-up study examining the relationship between IGF-1 and lipid markers after intake of the embryonary peptide preparation.
Human study · IGF-1 · Lipid markers · PubMed 18386621
3. Mihaescu G, Olinescu R, Constantinescu V, Toader M, Grigorescu A (2006). Regulatory modifications of steroidogenesis following the administration of embryonary peptides. Romanian Journal of Biochemistry, 43(1-4), 37-43. Request the paper →
A study examining changes in steroid-related biomarkers in human subjects after intake of embryonary peptides. The authors described the changes as adaptive-regulatory.
Human study · Steroid-related biomarkers · Full paper available to practitioners on request
4. Mihăescu G, Mihăescu I, Mihăescu O, Olinescu R, Oancea F, Gruia I (2005). Romanian Journal of Internal Medicine, 43(1-2), 149-163. Request the paper →
Older adults taking embryonic peptide preparations were monitored for markers of oxidative stress and antioxidant-related parameters over the observation period.
Human study · Oxidative stress · Full paper available to practitioners on request
5. Mihaescu G, Mihaescu O, Petrasincu D, Leabu M, Oancea F, Olinescu R (2005). Cytostimulatory and cytoprotective effects of peptides from chicken embryo on human fibroblasts. Preclinical File: Studies of Biological System Models. Research and Production Laboratory, Bucharest. Request the paper →
In laboratory cell cultures, peptides isolated from chicken embryo extract were associated with greater survival and growth of human fibroblast cells. The F2 peptide fraction showed the most pronounced effect.
Preclinical · Cell study · Full paper available to practitioners on request
The sections below present independent peer-reviewed research on biological compounds and signalling pathways found in the extract. These studies were not conducted on Oligenics. The presence of a compound in the scientific literature doesn't show that Oligenics, taken orally, provides it in a biologically active form or amount.
Section Two: Compound research library
Insulin-like growth factor (IGF). IGF-I is part of the insulin-like growth factor signalling system, which is involved in growth, development, metabolism and tissue physiology.
6. Radecki SV, Capdevielle MC, Buonomo FC, Scanes CG (1997). Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in the chicken following hatching. General and Comparative Endocrinology, 107(1), 109-117. View study →
Documented how levels of IGF-I, IGF-II and their binding proteins change in chickens during development after hatching.
Preclinical · Avian IGF · PubMed 9208310
Fibroblast growth factor (FGF). FGFs are a family of signalling proteins involved in cell proliferation, differentiation, development and tissue maintenance.
7. Nunes QM, Li Y, Sun C, Kinnunen TK, Fernig DG (2016). PeerJ, 4, e1535. View study →
A review of the FGF family's biological roles and the research into FGFs in tissue repair.
Review · FGF biology · PeerJ
8. Edirisinghe O, Ternier G, Alraawi Z, Suresh Kumar TK (2024). Biomolecules, 14(12), 1622. View study →
A review of FGF and FGF-receptor signalling mechanisms and their biological functions.
Review · Cell signalling · MDPI
Transforming growth factor beta (TGF-β). TGF-β is a family of regulatory signalling proteins involved in cell growth, differentiation, tissue remodelling and immune signalling.
9. Klass BR, Grobbelaar AO, Rolfe KJ (2009). Postgraduate Medical Journal, 85(999), 9-14. View study →
A review of TGF-β1's role in extracellular-matrix production, cell migration and tissue remodelling. Its effects depend on the timing, location and level of signalling.
Review · TGF-β signalling · Oxford Academic
Connective tissue growth factor (CTGF). CTGF/CCN2 is a signalling protein involved in extracellular-matrix regulation and tissue responses.
10. Kubota S, Kawata K, Yanagita T, Doi H, Kitoh T, Takigawa M (2004). Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. Journal of Biochemistry, 136(3), 279-282. View study →
A laboratory study found human platelets contain CTGF/CCN2 and release it during coagulation.
Preclinical · CTGF · Oxford Academic
11. Chen Z, Zhang N, Chu HY, Yu Y, Zhang Z-K, Zhang G, et al. (2020). Frontiers in Cell and Developmental Biology, 8, 593269. View study →
A review of CTGF/CCN2 structure, signalling pathways and biological functions.
Review · Extracellular matrix · Frontiers
Follistatin and activin. Follistatin is a binding protein that regulates activins, signalling proteins involved in cell growth, differentiation and tissue regulation.
12. de Kretser DM, O'Hehir RE, Hardy CL, Hedger MP (2012). Molecular and Cellular Endocrinology, 359(1-2), 101-106. View study →
A review of how activin A and follistatin regulate one another, and their roles in tissue responses.
Review · Activin/follistatin · ScienceDirect
MicroRNAs (miRNAs). MicroRNAs are small non-coding RNA molecules that regulate gene expression. They are found throughout biological systems, and research into dietary microRNA is ongoing.
13. Ajit SK (2012). Sensors, 12(3), 3359-3369. View study →
A review of circulating microRNAs, their stability in body fluids, and their roles in gene regulation and cell-to-cell communication.
Review · Cellular communication · MDPI
14. Fan J, Zhang G, Sun S, Zhang X, Li Y, Liu M, et al. (2026). Frontiers in Genetics, 17, 1832187. View study →
A review of how microRNAs are involved in ageing processes and in the lifespan effects of dietary restriction across model organisms.
Review · miRNA · Frontiers
15. Porcu C, Dobrowolny G, Scicchitano BM (2024). International Journal of Molecular Sciences, 25(11), 5811. View study →
A review of extracellular vesicles as carriers of microRNAs and other signals between cells. It notes that clinical translation remains limited.
Review · Extracellular vesicles · MDPI
Bioactive peptides. Research on food-derived bioactive peptides gives broader context on how peptides from foods are studied.
16. Wijesekara T, Abeyrathne EDNS, Ahn DU (2024). Effect of bioactive peptides on gut microbiota and their relations to human health. Foods, 13(12), 1853. View study →
A review of evidence on how food-derived bioactive peptides interact with gut microbiota and intestinal barrier function. It notes where further research is needed.
Review · Gut microbiota · MDPI
The references on this page are provided for information and education only. Section One studies were conducted on the ingredient used in Oligenics, by researchers affiliated with its manufacturer. The human studies used the original preparation at different numbers of capsules a day from the standard Oligenics serving of 2 capsules a day, for example 4 capsules a day in the lipid study and 2 capsules a day in the oxidative-stress study, over set study periods. Section Two studies are independent peer-reviewed publications that were not conducted on Oligenics. They give scientific context about biological compounds and should not be read as evidence of what Oligenics does. Where a paper's title refers to a medical condition, injury or treatment, the title isn't reproduced on this page; the full reference is available at the linked source or on request. This page is not medical advice. Oligenics is a food supplement and is not intended to diagnose, treat, cure or prevent any disease. Speak with a qualified healthcare professional before starting any supplement.